·Individual situations are assessed on a case-by-case basis, involving the patient in the discussion to secure her commitment, to discuss treatment options and to ensure that she understands the risks and t
As with other antiepileptics, taking valproate may be followed, instead of an improvement, by a reversible worsening of the frequency and severity of seizures (including status epilepticus) or by the appearance of new types of seizures in the patient. In case of aggravated convulsions, the patient should be advised to consult his doctor immediately (see section 4.8). These convulsions should be distinguished from those which may occur during a pharmacokinetic interaction (see section 4.5), toxicity (hepatopathy or encephalopathy - see sections 4.4 and 4.8) or overdose.
As this medicine is transformed in the body into valproic acid, it should not be combined with other medicines undergoing this same transformation in order to avoid an overdose of valproic acid (for example: divalproate, valpromide).
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New Zealand
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